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Neurotrophic Keratitis: Symptoms, Causes & Treatment in Orange CountyExpert Eye Care from Orange County’s Leading Specialists

Expert information about neurotrophic keratitis from Orange County's leading eye care specialists. Learn about symptoms, causes, diagnosis, and the latest treatment options.

Medically reviewed by Dr. Alexander Bonakdar, O.D. · Updated April 2026

What is Neurotrophic Keratitis?

Neurotrophic keratitis is a degenerative corneal disease caused by damage to the trigeminal nerve (cranial nerve V), which provides sensory innervation to the cornea. Without normal nerve function, the cornea loses its ability to heal and maintain itself, leading to persistent epithelial defects, corneal ulceration, and potential perforation — often with minimal pain because the cornea has reduced sensation. Common causes include herpes simplex or zoster keratitis, diabetes, acoustic neuroma surgery, and trigeminal neuralgia procedures. Scleral lenses protect the corneal surface and promote healing by maintaining constant hydration.

At EyeCare Center of Orange County, we specialize in the diagnosis and treatment of neurotrophic keratitis. Our experienced optometrists use state-of-the-art technology to provide comprehensive care and help preserve your vision.

Common Symptoms of Neurotrophic Keratitis

If you're experiencing any of these symptoms, schedule a comprehensive eye examination:

Persistent corneal epithelial defect that does not heal

Reduced or absent corneal sensation

Red eye with minimal pain (paradoxically)

Blurred vision

History of herpes eye infection, diabetes, or neurological surgery

Corneal thinning or ulceration

Treatment Options for Neurotrophic Keratitis

We offer comprehensive treatment options tailored to your specific needs:

Scleral Contact Lens Fitting

Cenegermin (Oxervate) — recombinant nerve growth factor

Amniotic Membrane Transplant

Autologous Serum Eye Drops

Tarsorrhaphy (partial eyelid closure)

Bandage Contact Lenses

Preservative-Free Artificial Tears

Why Choose EyeCare Center of Orange County?

Over 30 Years of Experience

Dr. Alexander Bonakdar has been serving Orange County since 1991 with specialized expertise in ocular surface disease.

Advanced Diagnostic Technology

We utilize the latest equipment for accurate diagnosis and effective treatment of neurotrophic keratitis.

Personalized Treatment Plans

Every patient receives customized care based on their unique needs and condition severity.

Comprehensive Eye Care

From diagnosis to treatment and follow-up care, we provide complete support throughout your treatment journey.

Frequently Asked Questions

What causes neurotrophic keratitis?

The most common causes are herpes simplex or herpes zoster (shingles) eye infections that damage corneal nerves, diabetes causing peripheral neuropathy, and surgical damage to the trigeminal nerve (from acoustic neuroma removal, trigeminal neuralgia procedures, or certain sinus surgeries).

How do scleral lenses help neurotrophic keratitis?

Scleral lenses create a sealed moisture chamber over the cornea, protecting the fragile epithelium from mechanical trauma (blinking) and dehydration. This environment promotes epithelial healing and prevents the cycle of breakdown and ulceration that characterizes neurotrophic keratitis.

Does insurance cover Neurotrophic Keratitis treatment?

Most vision and medical insurance plans cover diagnostic exams and medically necessary treatments. We accept most major insurance plans and can help verify your coverage before treatment.

Don't Let Neurotrophic Keratitis Impact Your Vision

Schedule your comprehensive eye examination today and get expert diagnosis and treatment.

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